Melamine is an important compound in organic chemistry. It is used in many different industries due to its versatility in different environments (temperature, acidity, etc.). There is a dark side to this compound which lead to massive infant sickness and death in China. Researchers are finding that long term complications are being seen in infants who consume melamine contaminated milk powder.
Melamine is described as a white, solid-like structure that is semi-soluble in water. It has a chemical formula of C3N3(NH2)3. In industry, it is primarily used to make a resin which is heat and fire tolerant. Whiteboards, floor tiles, kitchenware, fire retardant fabrics, formica countertops, and commercial filters are produced from the resin. The resin is produced by mixing urea with formaldehyde. When this combo is heated, it is easily moldable into desired shapes making this compound a versatile starting material for various products.
In 2008, China had a serious problem with melamine contamination in infant milk formulations. The chemical appeared to have been added to the milk to increase its protein content. Chinese food companies have been adding this compound to wheat flour. Usually the nitrogen content of a food is the marker used to measure the protein content. High protein foods are in high demand given the world’s protein demand and so economically, the strategy made sense.
The effects that the addition of melamine would have on health was not studied well enough. According to researchers, melamine, in high doses, can cause kidney stones and kidney failure in small animals. Because melamine is a crystalline structure, the urea in the body won’t effectively dissolve it all. The undissolved portions accumulate in the kidneys which can lead to kidney stones and kidney failure. Approximately 300,000 infants were sickened by melamine in China.
According to a study by the World Health Organization in October of 2008, melamine, when combined with cyanuric acid (also found in infant formula), forms crystals in the kidneys. Many companies and laboratories are now working on ways to detect melamine tainted products.
Since milk is an essential part of the human diet, especially in infants, the FDA guided its efforts to try and isolate the melamine-cyanuric acid complex. Milk is 88% water with the remaining 12% consisting of proteins, fats, and sugars. The additional vitamins and minerals such as calcium and potassium make it easy for melamine to disguise itself when contaminated. Scientists would first “clean-up” the milk sample by removing unwanted items. In theory, this should leave the analyte of interest (melamine). Scientists found that, by lowering or raising the pH level, the toxic melamine-cyanuric acid complex can be broken. This complex is held together by hydrogen bonds, which are relatively weak so by changing the system (acid or base) that this compound sits in, allows researchers to isolate the analyte. Once the sample is cleaned up, a technique called chromatography, or more precisely, high performance liquid chromatography (HPLC) allows researchers to purify the compound as much as possible.
According to the FDA website, it has contacted infant formula production companies and found that there is no melamine threat to infant formulas produced in the United States. These companies are reporting that they do not use imported formulas from China. For further information, you can log on to the FDA website and search for melamine which will bring you to a list of products that the FDA advises consumers not to ingest due to a possible melamine contamination.